Imruza 50mg Tablet 10pcs

✔️ Composition of Imruza 50mg Tablet

Azathioprine

✔️ Uses of Imruza 50mg Tablet

• Kidney Transplantation
• Rheumatoid Arthritis

✔️ Side Effects of Imruza 50mg Tablet

Common side effects of Imruza 50mg Tablet include infections, depression of bone marrow function, leucopenia, thrombocytopenia, nausea, and hypersensitivity reactions. Rare side effects include neoplasms, hepatotoxicity, and immune system disorders.

✔️ Quick Suggestions:

• Imruza 50mg Tablet should be taken orally at least 1 hour before or 2 hours after consuming milk or dairy products.
• Close monitoring of blood counts is necessary, especially in patients with an inherited deficiency of thiopurine methyltransferase (TPMT).
• Caution is advised in patients with renal and/or hepatic impairment, as well as in patients with Lesch-Nyhan syndrome.
• Special caution is advised in patients with renal dysfunction, and procedures for proper handling and disposal of the drug should be considered.
• Symptoms of overdose may include unexplained infections, ulceration of the throat, bruising, and bleeding, resulting from bone marrow depression. Treatment is supportive, with close monitoring of blood counts.

✔️ Indications of Imruza 50mg Tablet

Imruza 50mg Tablet is used in the management of organ transplantation. It helps the body to accept a transplanted organ like a kidney, liver, heart, lung, or pancreas. It is also useful in some autoimmune diseases including severe inflammatory diseases of the skin, liver, arteries, and blood disorders.

✔️ Pharmacology

Imruza 50mg Tablet antagonizes purine metabolism, potentially inhibiting the synthesis of DNA, RNA, and proteins. It may also interfere with cellular metabolism and inhibit mitosis. Its mechanism of action is likely due to the incorporation of thiopurine analogs into the DNA structure, causing chain termination and cytotoxicity.

✔️ Dosage & Administration of Imruza 50mg Tablet

The dosage of Imruza 50mg Tablet varies depending on the condition being treated. For renal homotransplantation, the initial dose is usually 3 to 5 mg/kg daily, adjusted based on individual patient response. For rheumatoid arthritis, the initial dose is approximately 1.0 mg/kg, with adjustments made based on response and tolerance. Maintenance therapy should be at the lowest effective dose.

✔️ Interaction

Imruza 50mg Tablet may interact with various drugs, including allopurinol, neuromuscular blocking agents, anticoagulants, cytostatic/myelosuppressive agents, methotrexate, vaccines, ribavirin, and aminosalicylate derivatives.

✔️ Contraindications

• If you are allergic to azathioprine or any other ingredients of Imruza 50mg Tablet.
• If you have a severe infection.
• If you have severe liver disease or severe bone marrow disease.
• If you have inflammation of the pancreas.
• If you need or are going to have a vaccination containing a living virus or bacteria, such as BCG, smallpox, or yellow fever vaccine.
• If you are pregnant or are breastfeeding.

✔️ Pregnancy, Fertility & Lactation

Pregnancy:

• Imruza 50mg Tablet is teratogenic, and caution is advised in pregnant women or those likely to become pregnant. Contraceptive precautions should be taken during treatment.

Mutagenicity & Fertility:

• Imruza 50mg Tablet has shown mutagenic effects, and its specific effect on human fertility is unknown.

Lactation:

• Mothers receiving Imruza 50mg Tablet should not breastfeed due to the risk of transmission of the drug and its metabolites to the infant.

✔️ Precautions & Warnings

Monitoring for toxic effects is essential throughout the therapy, especially in patients with renal and/or hepatic impairment. Close monitoring of blood counts is necessary, particularly in individuals with a deficiency of thiopurine methyltransferase (TPMT). Caution is advised in patients with Lesch-Nyhan syndrome.

✔️ Storage Conditions

• Keep the Imruza 50mg Tablet out of the sight and reach of children and pets.
• Store below 30°C in the original package.
• Discard off the expired and unused medicine appropriately.